Hendrik Doeff (1777-1835)
Hendrik Doeff won more trust from the Japanese than any other director of the Dejima factory. Doeff arrived in Japan in 1799 and assumed the position of director in 1803, but his tenure here was complicated by the annexation of the Netherlands by France at the time. Not a single Dutch ship sailed to Nagasaki from 1810 to 1817, and to make things worse, the "Phaeton" Incident and the attempted takeover of Dejima by the British took place during this period. Doeff nevertheless managed to weather these difficulties and to defend the Dejima factory, and he won honors from both the Dutch government and the Tokugawa Shogunate.
Jan C. Blomhoff (1779-1853)
Jan C. Blomhoff came to Dejima in 1809 as a warehouse foreman and served under Hendrik Doeff until 1813. He returned to the Netherlands but came back to Nagasaki again in 1817, this time with his wife, son and servants in tow. Blomhoff participated twice in the director’s regular journey to Edo and left his impressions to posterity in his diary of the journey.
 
Engelbert Kaempfer (1651-1716)
After studying philosophy, botany and medicine at universities around Europe, Kaempfer gained employment as an embassy clerk and later as a ship’s physician with the Dutch East India Company. He came to Japan in 1690 and stayed for two years, participating twice in the Dutch director’s regular journey to Edo. After his return to Europe he wrote “A History of Japan,” a groundbreaking work with detailed information on the history, religions, political system, customs and trade practices of this country. Kaempfer stands with Thunberg and Siebold as a pioneer in research on Japan.
Charles P. Thunberg (1743-1828)
Thunberg became a Dutch East India Company physician in the hope of collecting indigenous plants at the Cape of Good Hope and Japan. He arrived in Nagasaki in 1775 and participated in the Dutch director’s journey to Edo the following year, collecting specimens along the way and actively exchanging information with Japanese students of Western science. After returning to Europe he wrote several books introducing the native wildlife of Japan.
Philipp F. von Siebold (1796-1866)
Siebold arrived in Japan in 1823 hoping to conduct scientific research on Japan. Granted permission to open a clinic and school in a Nagasaki suburb, he taught medicine, zoology and botany to a large number of Japanese students and made a significant contribution to the study of Western science in this country. His romance with the Japanese courtesan Sonogi (Kusumoto Taki) resulted in the birth of a daughter named Kusumoto Ine who went on to become the first woman practitioner of Western medicine in Japan.
 
Motoki Ryoei (1735-1794) and Motoki Shoei (1767-1822)


Motoki Ryoei


Motoki Shoei
Motoki Ryoei is famous for introducing the Copernican theory to Japan and for writing and translating a large number of works on subjects such as astronomy and geography. His son Shoei, at the behest of the Shogunate, began studies of the English language at the age of 43 with his fellow interpreters and went on to compile Japan’s first English dictionary. He also studied French and compiled a dictionary of that language.
Yoshio Kogyu (1724-1800)
A native of Nagasaki, Yoshio Kogyu became a student interpreter at the age of 14, rose to the position of head interpreter at 25, and went on to serve in this position for more than 50 years. His expertise extended from linguistics to astronomy, geography and Western medicine. After studying under Thunberg, he established the Yoshio School of Surgery, instructed a large number of prominent students and made significant contributions to the development of Western science in Japan.